LAB PROTOCOLS

Neural tissue cell culture

  • Isolation of spinal cord and DRG neuron
  • Isolation of LMMP and myenteric plexus
  • Enteric neuronal cell culture
  • IPSC-derived neural tissue organoid

Viral package and gene delivery

  • AAV and systemic delivery for CNS and PNS
  • Lenti-viral package

Immune cell isolation and culture

  • Bone marrow macrophage culture
  • Bone marrow DC culture
  • Neutrophil isolation from BM and periphery
  • IEL and LP isolation for immune profiling
  • ER-Hoxb8 system

Mouse models

  • Food allergy model
  • IL-4C
  • DSS colitis model
  • AIEC infection
  • EAE model
  • B16 melanoma model
  • Prostate cancer xenografts

Immuno-assay

  • Whole mount GI IHC and IF

Gut permeability and motility assay

  • FITC dextran assay
  • Carmine-red dye assay
  • PAS staining
  • Ussing chamber

CRISPR pooled screen

  • Optical pooled screen
  • IBD & Genome-wide CRISPR library screen

Spatial transcriptomics

  • STARmap
  • Visium
  • Slide-seq
  • Nanostring